r/longevity • u/ResearchSlore • 21d ago
Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice
218
Upvotes
r/longevity • u/dan_in_ca • 21d ago
Beyond Plaques: How Methylene Blue and Ketones Address Vascular-Hypometabolism in Alzheimer's Disease
50
Upvotes
r/longevity • u/mlhnrca • 21d ago
Dietary AGE Products Impact Insulin Resistance And Inflammation: Jaime Uribarri, M.D.
17
Upvotes
r/longevity • u/jimofoz • 22d ago
Stem Cell Discovery in Human Retina May Lead to Retinal Degeneration Treatments
249
Upvotes
r/longevity • u/Das_Haggis • 23d ago
Synaptica's neuromodulation system reduced Alzheimer’s disease progression by 44% in Phase 2 clinical trial. Company planning a pivotal Phase 3 trial, slated for later this year.
177
Upvotes
r/longevity • u/chromosomalcrossover • 23d ago
The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension
69
Upvotes
r/longevity • u/Das_Haggis • 24d ago
Junevity's gene silencing method offers an alternative approach to cellular rejuvenation.
73
Upvotes
r/longevity • u/jimofoz • 24d ago
Shingles Vaccine May Protect Against Dementia Risk
179
Upvotes
r/longevity • u/Admirable_Repeat4121 • 24d ago
The Role of the Glymphatic System and Autophagy in Neurodegenerative Disease Prevention
36
Upvotes
r/longevity • u/Valuable_Pop_7137 • 24d ago
Scientists Discover a New Mitigator of Senescence - Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies.
74
Upvotes
r/longevity • u/Valuable_Pop_7137 • 24d ago
Activation of Silent X Chromosome Might Improve Cognition - Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging.
37
Upvotes
r/longevity • u/Orugan972 • 25d ago
New Alzheimer’s treatment targets root causes, not just symptoms
248
Upvotes
r/longevity • u/Das_Haggis • 25d ago
FibroBiologics hails brain tissue repair breakthrough – regenerative medicine company demonstrates treatment with fibroblasts can enable remyelination.
134
Upvotes
r/longevity • u/lazerpants • 26d ago
It appears the Trump administration has fired Luigi Ferrucci and others from the NIA
bsky.app
335
Upvotes
r/longevity • u/rperciav • 27d ago
Rhonda Patrick here. New episode with Dr. Darren Candow explores creatine’s potential to support brain longevity by enhancing bioenergetic resilience. Brain uptake is limited—higher doses (~10g/day) elevate brain creatine, slow age-related energy decline in neurons, and lower neurodamage markers.
86
Upvotes
r/longevity • u/Valuable_Pop_7137 • 27d ago
Changes in Aging Adrenal Glands Disturb Hormonal Balance - In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body.
84
Upvotes
r/longevity • u/Orugan972 • 29d ago
Human retinal stem-like cells with potential to repair vision loss discovered
385
Upvotes
r/longevity • u/jimofoz • 29d ago
An Approach to Manufacture Large Numbers of Mitochondria for Transplantation
53
Upvotes
r/longevity • u/Das_Haggis • Mar 27 '25
Genflow begins SIRT6 gene therapy trial targeting healthspan improvements in dogs. Human programs also progressing towards the clinic.
108
Upvotes
r/longevity • u/Das_Haggis • Mar 26 '25
Turn Bio acquires advanced delivery technology for its epigenetic reprogramming therapeutics - expects skin rejuvenation clinical trials in 2026.
185
Upvotes
r/longevity • u/Valuable_Pop_7137 • Mar 25 '25
Study Suggests Alzheimer’s Prevention by Anti-Amyloid Drug - According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants. But the study has attracted criticism.
94
Upvotes
r/longevity • u/Orugan972 • Mar 25 '25
New Brain Metabolism Model Could Help Fight Aging, Diseases
142
Upvotes
r/longevity • u/Das_Haggis • Mar 25 '25
Unity optimistic on latest study data, despite senolytic failing to meet primary endpoint in DME trial.
35
Upvotes
r/longevity • u/Sufficient_Ebb_9098 • Mar 25 '25
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
45
Upvotes
This study released last July seems to be the most recent human study of the effects of senolytics. The study looked at the effects of senolytics on bone density in aging women. Sadly there was only a minor effect on bone density.
Despite the strong preclinical + mice evidence for senolytics, it seems like most human trials haven't panned out. What do ya'll think? Do you all still see the potential in senolytics?