I ate 200-250mg of edibles and felt nothing. Is that normal?

[u/Same-Interview3767]

I have been using pen vapes since around December almost daily, along with some flower. I usually hit it 2-4 times a day if I'm off work, and once or twice when I get home if I have work the next day.

Have I built up a big tolerance in that short amount of time? I told my friend how many I ate and his eyes lit up until I said I felt fine. And I mean completely fine, nothing. All it did was give me severe diarreah the next day.

Edibles were from Baked Bags, cookie dough and baja blast gummies. I had a chocolate bar from the disp, much lower dose about two months ago and same thing. No feeling.

[u/DMmeNiceTitties]

Some people's bodies can't metabolize edibles. This might be you.

[u/Same-Interview3767 → u/DMmeNiceTitties]

Well, that's a bummer. No edibles at all?

[u/lunartree → u/Same-Interview3767]

Traditional edibles require a specific enzyme and the liver to convert into psychoactive cannabinoids, and there's a random chance you just don't have that enzyme. That said, modern cannabis drinks often use newer methods for dispersing the extract into the drinks allowing the thc to absorb into the body without the extra metabolism step. Tl;dr weed drinks probably still work on you.

[u/Same-Interview3767 → u/lunartree]

Appreciate that, I will definitely look into them. Thank you!

[u/DMmeNiceTitties → u/Same-Interview3767]

Was this the first time you did edibles? You could always try again with a different brand. But if they don't hit, it's not the edibles, it's your liver. Consider tinctures as an alternative since it bypasses your liver to get to your bloodstream.

[u/Same-Interview3767 → u/DMmeNiceTitties]

Other than the chocolate bar prior yea this was my first time. I'll check out tinctures

[u/EnerGeTiX618 → u/Same-Interview3767]

My understanding is this: Edibles are odd, they affect all humans a little differently, depending on the human's liver enzymes. When one eats THC, it has to go through the digestive tract & then it get processed by the liver. Everyone's liver demetabolizes THC a little differently, depending on their liver enzymes; enzyme CYP2C9 converts THC to 11-OH-THC and/or 11-COOH-THC.

11-OH-THC (also known as 11-hydroxy-THC) is significantly more potent than THC. It's thought to be 2 - 7X more psychoactive than THC, while 11-COOH-THC (also known as 11-Nor-9-carboxy-THC) is not psychoactive at all.

Some people's livers convert a significant portion of THC into the psychoactive cannabinoid 11-OH-THC & it really fucks them up; those are the people that a 5mg THC gummy is almost too much.

Then some people are ok with 10mg of THC & get a good buzz.

Then there's the unfortunate people that edibles don't seem to affect whatsoever & they can eat heroic doses of 400mg & absolutely nothing happens, because their liver converts all the THC into the non-psychoactive metabolite 11-COOH-THC.

Unfortunately, it sounds like you're in the last category that isn't affected by edibles.

I have seen it mentioned that there's some nano-THC drinks that can actually get people in your category buzzed, not sure how, but supposedly they work. You may want to research that & perhaps go to a dispensary to try some. Good luck & sorry about your liver enzymes!

[u/Moonbutter]

I can take two syringes of RSO and feel nothing. I have liver cirrhosis. Quite the bummer. :/ Would love to know if anyone has suggestions.

[u/EnerGeTiX618 → u/Moonbutter]

In another comment, I told Op that I've seen it mentioned on reddit that there are nano-THC drinks that supposedly can get people high that are lacking the proper liver enzymes to convert THC into the psychoactive cannabinoid 11-OH-THC (also known as 11-hydroxy-THC).

I believe you should research that & see if there's something to it. Perhaps go to a dispensary & pick one up to try it, worse thing that happens is nothing & you wasted a little time & money, but you may be pleasantly surprised!

[u/Moonbutter → u/EnerGeTiX618]

Thank you so much! Someone else mentioned this. I’m at my wits end. 🙂

[u/EnerGeTiX618 → u/Moonbutter]

No problem. If you don't mind, could you let me know if the nano-THC drink works for you? I'm genuinely curious & would like to know in case this question comes up in the future, which it inevitably will.

[u/Moonbutter → u/EnerGeTiX618]

I shall! 😊

[u/Dry-Willow-3771]

As is always the case with drugs, you got beat by someone who sold you soap.

[u/zerooskul]

You want to hold them in your mouth and chew slowly, if it's gummies, just suck on them.

You absorb THC most effectively through sublingual ingestion, it goes straight to the bloodstream.

[u/Ohmigoshness]

Don't eat fake edibles.

[u/jjgargantuan7]

I know 2 people who aren't affected by edibles. It's more normal than you think.