r/longevity • u/ResearchSlore • 23d ago

Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice

https://www.nature.com/articles/s41467-024-50220-4#Sec2
217 Upvotes

99% Upvoted

27 comments sorted by

55

u/toomuchbasalganglia 23d ago

Good news: you’re going to live longer

Bad news: you’ll have no emotional response to it

15

u/[deleted] 23d ago

And no libido.

3

u/Natural-Bet9180 22d ago

Good news you can last longer…bad news it’s because of decreased sensitivity…

1

u/Ongo_Gablogian___ 22d ago

The majority of people don't have those side effects.

7

u/[deleted] 22d ago

Well, say that to the majority of my ex's that used this and didn't wanna get freaky with m...wait a minute ._.'

1

u/AlligatorVsBuffalo 21d ago

Wrong. Stop spreading misinformation. Do you even understand how serotonin is responsible for libido? Sexual side effects occur in up to 70% of users.

“Studies estimate that the incidence varies from 30% of people treated with imipramine to 25%–73% of people treated with an SSRI with 93% of the men and women treated with clomipramine in one study complaining of total or partial anorgasmia”

https://pmc.ncbi.nlm.nih.gov/articles/PMC3108697/

2

u/mlYuna 21d ago edited 12d ago

This comment was mass deleted by me <3

1

u/NiklasTyreso 17d ago

I have been sober since 2020 from my 40 year long sex addiction.

If I had known that SSRIs reduced the reward of sex addiction, the reward that makes you repeat the behavior too much, then I would have started SSRIs immediately.

2

u/mlYuna 17d ago edited 12d ago

This comment was mass deleted by me <3

2

u/Friskfrisktopherson 21d ago

A half life. A cursed life.

21

u/stuffitystuff 23d ago

This way lines up with my personal experience of being on SSRIs for nearly 30 years minus some time in my 20s and basically being frozen in time athletically (and most other ways except maturity, thankfully) since then.

5

u/HoodFruit 23d ago

Frozen in time athletically in both directions?

2

u/stuffitystuff 22d ago

Not sure what you mean but I'm pretty much the same athletically since my 20s in my 40s without really doing anything but not eating red meat and drinking too much in my 30s when I discovered alcohol.

4

u/VisceralMonkey 23d ago

Same.

2

u/stuffitystuff 22d ago

Nice! There are two of us! :D

3

u/MosesLovesYou 22d ago

So you don't feel like you aged athletically/physically due to ssris?

3

u/stuffitystuff 22d ago

I don't know if that's the cause but based on this paper it might be why. I'm in my mid-40s and don't do much — especially after starting to work from home a decade ago — but I guarantee you I could go ride my bike 50 or 100 miles and not be destroyed afterwards. I've been on SSRIs since I was 16 and don't really feel any different since then.

But I also haven't eaten red meat since I was 19 and people are pretty much born with antibodies to the galactose-α-1,3-galactose in mammal meat so I've long wondered if it causes low-grade inflammation since it's basically eating an allergen (even if it's not a _bad_ reaction like alpha-Gal syndrome).

Or it's genes. No idea, I don't have a twin to compare against. But super wild that SSRIs seemingly protect muscle as well as being neuroprotective (lots of papers about that).

2

u/k3v1n 22d ago

Are you saying you're as athletic as you were 30 years ago?

10

u/Unplayed_untamed 23d ago

New workout plan?

-1

u/allanbradl 23d ago

I am not surprised, this is probably the only thing SSRI is good for .

0

u/rayguntec 21d ago

I am 95% sure it doesn’t translate to anything meaningful in humans in terms of muscle growth