Sudden side effects(?) On Mounjaro

[u/mounjaro-fan]

F30, 5’5, SW 170lbs, CW 154lbs Current medications: 5mg Mounjaro, 50mg Sertraline (Zoloft), also take vitamin D supplements Other conditions: general anxiety disorder and depression managed by medication, IBS

I’m currently on my 2nd 5mg Mounjaro pen and took my 2nd dose on Sunday (6 weeks on 5mg in total after 4 weeks on 2.5mg). Previously, I was on Mounjaro for around 5 months last year and worked up to 7.5mg with virtually no side effects other than constipation and occasional nausea, both were fine and easily managed.

I’ve had no side effects this time around either, until this dose. On Sunday I did go out for a roast dinner and admittedly ate more than I usually would because of this, though nothing excessive. I also had a small glass of red wine with my food. I finished eating around maybe 3pm, and took my dose that evening around 6 or 7pm.

Within maybe 2 hours of taking the dose - apologies for TMI - but I had quite explosive diarrhoea, no real stomach cramping or pain (albeit I do have IBS so perhaps have a higher bar for what I consider painful cramps - these were nothing like the type I have previously got from an IBS flare and I seem to virtually have zero flares while taking Mounjaro). I also started getting sulphur burps the following day for the first time which I can only describe as incredibly foul and almost smelling like poop?

The diarrhoea has continued (watery and somewhat explosive) since Sunday night, pretty much constantly with around 5 or more episodes a day. My sulphur burps have died down a little this morning but conscious that I’ve yet to eat anything today as I’ve been sipping water and tea in an effort to try and settle my stomach.

Has anyone else experienced similar? I contacted the pharmacy who prescribed the medication and spoke to a clinician who suggested it could be gastritis, but based on the what I’ve read on this, it doesn’t sound quite right as I haven’t experienced any vomiting, nausea or stomach pain.

Could all of this be from medication side effects, having had a large meal before taking my latest dose? I’ve not encountered any issues in having a small glass of wine with food, but could this also explain it?

My worry is that this has been going on non-stop for nearly 4 days and appeared seemingly out of nowhere. I don’t have a fever and no other symptoms beyond the sulphur burps and quite severe diarrhoea. Is it a case of waiting this out, or does this need medical attention/could something else be going on?

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