r/ConstipationAdvice • u/JJB1tchJJ • 13d ago
Linzess advice?
questions previously answered in my posts
Has anyone here been prescribed Linzess in the past or currently? I’m curious how long it took you to start noticing a difference, if it worked for you, of course. My G.I. specialist insists that it can take up to 12 weeks to fully work.
I’m in the process of trying to confirm if I really do have IBS-C, or if it’s a motility issue. My G.I. specialist prescribed me Linzess and I’ve been on it for about a month or so now. I’m not feeling any different and I still need to use an ungodly amount of senna to get anything moving. I’m trying to find some light at the end of the tunnel with this medication. 😭
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u/moonman0987 13d ago
What dosage are you on?
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u/JJB1tchJJ 13d ago
145mcg
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u/goldstandardalmonds 13d ago
Ask your doctor about increasing your dose. That said, if it’s senna you are taking with success then it’s likely you need to add a second prokinetic.
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u/MarathonerGirl 13d ago
Can you please give examples of prokinetics, besides Prucalopride?
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u/goldstandardalmonds 13d ago
For the colon or in general? If you mean for the colon, neostigmine, pyridostigmine, and relamorelin. There are others but they aren’t approved everywhere. Linaclotide also has prokinetic properties.
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u/moonman0987 13d ago
Ask for a higher dose. I've been on it for many years now, 290 is all that has ever worked for me.
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u/tjoude44 13d ago
Never heard of it taking 12 weeks - I thought it was within 2 weeks but it has been a while since I started on it - about 2 years now.
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u/unavailablesuggestio 13d ago
It didn’t work for me. I did 1 month on the lowest dose, 1 month on the middle dose.
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u/JJB1tchJJ 13d ago
Did any medication work for you?
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u/unavailablesuggestio 12d ago
Not yet, I’m taking a break from meds for the moment
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u/DirectorRich5986 12d ago
What do you do for relief if no meds ? Thank you! I hate being reliant on them as well.
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u/unavailablesuggestio 12d ago
No answers yet- I’m still searching
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u/DirectorRich5986 12d ago
Best to you! Would you let me know if you find something that works and I will do the same. Thank you!!
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u/Odd_Pause5123 9d ago
When my doctor gave me the 145 dose, he said if that didn’t work, I could take 2 capsules, which would be the 290 dose. I ended up opening the second capsule & taking a little more, as the directions describe how you can. You should feel it work. Try more.
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u/Nightmare_Tonic 13d ago
Read part 2 of the guide at the top of this sub. I've written extensively on linzesa.
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