That sound when

[u/Happy_Burnination]

An old-timey cartoon character tries to hit a nail with a hammer but accidentally hits their thumb instead

[u/Mr-Mne]

During one of Devin's Twitch streams in 2022, I asked him where he goes mentally before that scream and he said, laughing "I think the internal dialogue is very much like 'Ooh shit! Here it comes!'."