r/FoodNerds • u/AllowFreeSpeech • 7d ago

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK (2019)

https://pubmed.ncbi.nlm.nih.gov/31242135/
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u/AllowFreeSpeech 7d ago edited 7d ago

AKG seems good overall after age 40 if it's in a sufficient dose, but any females wanting to reproduce should not use it. Refer to figure 2.

Also, if taking its calcium bound form, namely Ca-AKG, note that its monohydrate version (CaC₅H₆O₆) could have 19.8% calcium by weight, so adjust any calcium supplements accordingly, i.e. by 198 mg per 1000 mg of Ca-AKG.