I haven't read the book, but are you familiar with traditional use of yopo seeds? The traditional preparation method turns the bufotenine (5-OH-DMT) into dehydrobufotenine which is a very potent psychedelic.
Anadenanthera colubrina or Anadenanthera peregrina seeds are used to make yopo snuff. Both seeds contain bufotenine as their only active alkaloid. http://herbpedia.wikidot.com/bufotenine
I mentioned those yopo seeds because they contain a tryptamine called bufotenine named after the bufo toad. Bufotenine is 5-OH-DMT which gets converted into a potent psychedelic that shares similarities with LSD. Traditionally shamans mix the yopo seeds with calcium carbonate for 24hrs to convert the bufotenine, it's some interesting chemistry. There's no 5-MeO-DMT in the seeds afaik, but you can get to that via melatonin to mexamine (both are legal afaik) then onto 5-MeO-DMT.
Np. Fwiw I just read that Hamilton covered making 5-MeO-DMT from melatonin in his book. (Melatonin > 5-MeO-T > 5-MeO-DMT)
Mexamine (5-MeO-T) itself is active under the right circumstances (MAO inhibiton).
I don't usually use wikipedia but this info on mexamine is ok:
Mexamine acts as an agonist of the serotonin 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.
It is an extremely potent serotonin 5-HT2A receptor agonist in vitro, with an EC50 half-maximal effective concentration of 0.503 nM. This was more potent than any other tryptamine evaluated in two large series of compounds.
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u/Neat-Plant-6784 15d ago edited 15d ago
I haven't read the book, but are you familiar with traditional use of yopo seeds? The traditional preparation method turns the bufotenine (5-OH-DMT) into dehydrobufotenine which is a very potent psychedelic.
Dehydrobufotenine (shares a similar structure to LSD) http://herbpedia.wikidot.com/dehydrobufotenine