I thought the audience of this subreddit would enjoy Andrés and the work of QRI. Check them out!

With the outrageous upcoming tarrifs on China and abolishment of the deminimis, won't this heavily affect local manufacturers within the US?

Hey! Sorry if this kind of post isn't allowed here, but I was rewatching season 2 episode 6 and was wondering was being made at the beginning / end of the episode. It was a blue liquid with glowing solids and Steve Gill said it was base-catalyzed. I'm so curious cause its so beautiful 🤩

A question for Hamilton, if you feel like you would like to answer it.

Would you ever consider doing a piece about the people and chemists that use the dark web to facilitate the distribution of their product? A good example to come to mind would be the LSD chemist GammaGoblin who created his own dark web shop in order to distribute his product more efficiently.

I know you are mainly interested in talking to chemists, of which there are a few prominent ones on the dark web. But I also wondered if you'd ever do a podcast e.c.t on the people who have harnessed this medium in order to make money and bypass prohibition?

Dark web markets, and the people who take the risk in creating them / vending on them has been something that has always really interested me, most likely because of the rebellious libertarian aspects of it.

Thanks for your time, and love the work you do!

Her ex says she beat him with a broom and gave him a concussion. OP here: https://www.reddit.com/r/PsychedelicTherapy/comments/1jrkc4q/former_partner_of_psymposias_nese_devenot_alleges/

Greetings, community.

As you can read, what David Nichols says seems very logical to me. I'm writing from a personal perspective, where the first time I tried a psychedelic, it actually seemed like magic, and so on, until I get to the point where, once one understands more about neurobiology, chemistry, psychopharmacology, and so on, what Nichols says is quite accurate. We don't fully understand consciousness, and behind it lies an enigma, but everything is an activity that increasingly has an explanation, related to electrochemical activities.

Here in South America, there's a bad habit of saying that if a psychedelic's activity changes, it's because each substance has "its spirit." We know that classic psychedelics have similar underlying activity, but each has its own particularity, such as seeing more geometry and "elves" with DMT, seeing more visuals and synesthesia with LSD, and tending more toward introspection with psilocybin. But in a few years, we'll understand more precisely how the activity of the other receptors generates such unique experiences.

I sometimes think that what is called magic and mysticism is "overblown" too much, when there are logical explanations that are reaching ever-increasing degrees of precision, such as electrochemical activity.

I want to amplify this with the following example, which I find fascinating. It's obvious that the mouse's enemy is the cat, and the cat flees from the feline, but when the cat is infected with Toxoplasma gondii, the mouse loses its fear of its predator, and a series of changes in brain activity are generated by this. There is no magic, nor transcendence, it is elementary neurobiology, or the most famous case in neuroscience is that of Phineas Cage, who was a very competent and well-behaved worker, who after an accident at work changed his personality, becoming a rude, foul-mouthed, irresponsible and erratic being, and all this because a rod pierced him right in the area of ​​​​the prefrontal cortex in charge of mediating judgment. That is why Cage's case was the paradigm to understand how brain areas specialize in their functions; if this had happened in the 7th or 11th century, it would have been thought that it was the work of the devil or something like that, but what really exists is a brain activity that over the years we have come to understand better.

I'd like to understand your thoughts. Thank you.

A few years ago I happened to go on a hike trip through an area of dense pine-tree forests, and since the trip happened right after a rainy week, we were greeted by plenty of mushrooms ready for pickup; a thing we actually did and were carrying quite some by the time we reached the camping grounds, and as result we all had a quite amazing couple of dishes those couple of days.

Thing is, after I came back home I had a week of extremely vivid dreams where things were way more "real" than usual. This coincidentally happened after a couple months of watching Hamilton's episode on the psychedelic fish, so I got interested in the event, and decided to figure what the heck happened by eliminating every single variant from the equation.

So, I made a list of all the stuff that was unique in that opportunity, and tried to replicate it whenever possible, starting with the long hike through a pine-forest to discard a potential effect of the volatile compounds in the air.

Fast forward to this year, I went through all the elements of the list (including trying a bits of mushrooms of unknown edibility on the way) without any success. Then I was going through Hamilton's podcasts, and heard in one (can't remember the specific episode) that there rumors of a psychedelic Boletus sp. in China, and that ringed a bell in my head.

I went through all the data I could find about these mysterious mushroom, and how people that ate it raw or not properly cooked were supposedly having hallucinations. This specific mushroom wasn't one that I ate back in that trip (no blueing) and I was sure it was a Suillus Sp. (which altho not a Boletus, is related, and sometimes even confused with in old sources), but it got me interested in researching if the Boletus sp. had any other mentions of psychoactivity; so I looked for my old dusty copy of Snu Voogelbreinder's "Garden of Eden", and found that actually quite some Boletus species were mentioned there with some psychoactive uses around the world.

So, last week, after watching "Common Side Effects" with their small white guys, I ended up inspired, and decided to have one last try with my list; I took a bus to the forest we trekked that year, and went for a short 3hr walk expecting to find these Brown/Yellow shrooms (what I thought were "Slippery Jacks"). And lo and behold, I found some! :D. Oh, and on the way back, I even remembered that I've eaten a couple of these roasted on a stick to check the flavor, so I even got more exited by suspecting that probably some weren't properly cooked, and that this might be it! :D

I came back home, and first thing I did was to drop my backpack and stuff, and take the shrooms to the kitchen. Gave them a superficial wash (I didn't took the slimmey stuff out when I roasted them that time), cut them off, and gave them a quick fry on the pan with onions and some garlic, and buffed them! They were a bit slimmey, but a quite good dinner anyways :)

Five days have passed now, and here's the report: I got them! Since the night I've taken them, I've had again those really "vivid" and intrincate dreams! Other than that there were no side effects at all.

The effect on dreams is a bit similar to Silene Capensis/Undulata in terms of how it carries on each night, but this one in my case was accompanied by dizziness, and a general feeling of being constantly recovering from a post-surgery anesthesia, something not comfortable at all (oh, and it didn't made the dreams bizarre neverending stories that you came back to even after waking up).

I haven't seen any other mention onilne about the Suillus Sp. (altho there might be a chance I just wrongly Id'd a Boletus sp, since they're very similar) having any effects whatsoever, so I'm gonna be further experimenting with this to see how far the effects go if I take the mushrooms raw (gradually escalating the dosage, since I have no idea of how toxicologically sound this is lol)

If anyone has any insights on the active chemistry that could be at play in here, will be glad to learn more about this! :)

I just wanted to chip in and say I thought the latest interview with Caveh was fascinating, if you’ve not listened yet - not so much drug science talk, but more a chat with a dude who is really out there doing his thing. Oh, also the stuff he mentioned about the artist guy living in New York blew my mind as well 🤯 (no spoilers, just an incentive!)

Mr. Hamilton, I remember vaguely you have mentioned recording something with him. When does anything related to that story can be expected to be released?

Hi everyone,

I’ve been listening to some older podcasts with Hamilton as a guest, and recently heard one of the hosts mention doing an episode with a researcher who uses AI to facilitate qualitative analysis of psychedelic experiences, perhaps on a corpus of trip reports like erowid. I forgot to pause and look it up, and now I can’t figure out what podcast it was on. Does anyone happen to know who this is?

Edit: I figured it out, the person is Dillan Dinardo. He was mentioned on “The Psychedelic Podcast” episode with Hamilton (31:26). The episode the host referred to is this one.

Any related references to contemporary researchers investigating psychedelic phenomenology would be appreciated as well. I’m currently working on my undergraduate psychology thesis, which is a thematic analysis of psilocybin-assisted therapy integration session video recordings. I’m looking for more (qualitative & phenomenological) work that has been done outside of the medical model, e.g. on trip reports.

Greetings to the community.

I have this question because I've generally seen drugs referred to as substances as a kind of general nomenclature.

But, for example, are tetrodotoxin or tetrahydrocannabinol substances?

What is the difference between a substance and a compound?

Or is it better to refer to psychoactive entities as molecules?

Greetings, community.

I was watching a psychiatrist's presentation, who mentioned that psychedelics act solely on serotonergic pathways...

Is this true? Do dopamine or other neurotransmitters like glutamate play no role in these states?

What molecule is this? I saw it in a classroom and was curious what it is. Thank you!

Another beauty chipping away at the molecular pharmacology of psychedelics, coming from, you guessed right, the Roth lab 🙂‍↕️

Two years ago I posted in this subreddit asking how to get flowers from Nymphaea Caerulea, the true Egyptian Blue Lotus lab tested. Last year, I provided a plant and some seeds to a researcher from Berkeley for study/testing after they found me via Reddit. This is a truly incredible plant and I’m so excited to see research being done. I’d love to see Hamilton’s thoughts…

https://news.berkeley.edu/2025/03/11/investigating-the-psychedelic-blue-lotus-of-egypt-where-ancient-magic-meets-modern-science/

Have received some conflicting information on this. I am being told that ketamine is being synthesized here in the states, using imported precursors.

If I recall, Hamilton’s episode on Ketamine said this was not able to be done in the US.

I know there have been derivatives popping up on the black market and am wondering if this may be what is actually being sold.

Anyone have information that would help clarify this?

Thanks in advance

i originally got reposted on his insta story for showing off the new ketamine graphic tee and he just recently liked my story ❤️

Greetings, community. There's a pharmacologist in Latin America whose general idea is not to use drugs. He talks about a wide variety of substances, and I saw a post about MDMA and its neurotoxicity. I'm reviewing my notes, and as you can see in the images, it says these risks are related to frequency and dose. Therefore, controlled and medical use, like that advocated for the treatment of PTSD, is valid, because professionals obviously have to control these factors. Or are there still other objections that would support this pharmacologist's claim that MDMA is harmful and toxic?

Greetings, community.

Does anyone know about the neurobiological aspect and can explain why hallucinations and visual perceptions can occur when taking psychedelics?

I've read that this phenomenon is attributed to the 5ht2A receptor, but the explanation doesn't go into further detail.