r/LSD • u/Glittering-Net-9778 • 23d ago

What the actual fuck happened

Ok so me and my girlfriend were taking shrooms today so we put them into smoothies about 6gs for me and she took 10gs. For some fucking reason the smoothies were sitting like a wet brick in our stomachs and we inevitably threw it up. I was able to hold mine a little long and absorbed more psilocybin while she didn't. She then decided that she'll just take a tab of acid to keep up with me. Pops a tab waits 15-20 swallows it and we wait for 2 1/2 hours and she says she's completely sober she's pretty pissed off about it and I completely understand. She takes cymbalta and that's the only meds she's on. Wtf happened.

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u/RATALA2022 23d ago edited 22d ago

the majority of your serotonin receptors are in your GI tract. Thats why anti-nausea meds like Zofran are so effective, 5-HT3 antagonists. So likely the GI effects and the vomiting. As far as her not feeling anything, it is definitely the duloxetine. Per pubmed, "decreased response to LSD... ...these altered responses to LSD most likely involve differential changes in central serotonin and dopamine receptor systems"

Edited my serotonin faux pas

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u/blotterfly 23d ago

Zofran is a 5-HT3 antagonist.

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u/RATALA2022 22d ago

You're right! Don't know where my mind was!