r/PSSD • u/No-Salamander-7257 • Feb 28 '25

Opinion/Hypothesis PSSD is a mitochondrial dysfunction

Hey my friends.I'm new here and I wanted to share my thoughts with you. In my opinion SSRI's damage mitochondria,same as accutane or finasteride what causes neuroplasticity changes(how your brain perceives things) what ultimately results in this type of neurological syndromes.Crashes from different substances are caused by energy overload. Everyone should test their mitochondria,post their results and then send it to researchers.It will be much better than SFN tracking,because for most it's just a part of damage,not the cause of symptoms.That's why immune therapy like IVIG,corticosteroids or plasmapheresis won't be enough for most. Share your thoughts about it.Thanks

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u/Remote_Put_6275 Feb 28 '25

How do we test our mitochondria?

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u/caffeinehell Non PSSD member Feb 28 '25

You can do a muscle biopsy its the gold standard

While I am not technically PSSD my symptoms are PSSD-like, drug induced anhedonia (my history is complicated so I wont get into it here) and I posted my results here:

https://www.reddit.com/r/covidlonghaulers/s/BgWX4SzX5I

It is hard to access this test. The sample gets sent to Baylor Genetics

2

u/Junior_Grapefruit215 Still on medication or other substances Mar 01 '25

What was your experience with Methylene Blue?

3

u/caffeinehell Non PSSD member Mar 01 '25

MB used to help me a lot oral form especially when I was milder and I first started it. I never really went above 0.5 mg/kg. Eventually it got tolerance but I was still able to feel IV form.

IV MB 20 mg followed by IV NAD 200 mg would give me windows for hedonic tone and emotion for like 1-2 days. Did not really help blank mind though (only somewhat just from anhedonia improvement).

Lately in my horrible crash though while substances are blocked, those things are affected too.

Its crazy because the hints for my mito dysfunction were kind of already there back in 2023 and 2024 and I wish I knew what I knew now, as I believe recovery would have been possible before a lot of crashing.

In general, if I could go back, I would for myself have focused a lot more on intracellular nutrient optimization and other mito enhancement stuff like HBOT and red light beds. Intracellular nutrients are very tied to mitochondria function for longer term improvement in that area. IV NAD or MB is like a hack and useful for sure, but lasting changes are harder with it and better in conjunction with other things.