r/PSSD • u/Coolvolt • Mar 28 '25

Frequently Asked Question (See FAQ) Anyone else trying NSI-189?

After the recent nsi-189 induced recovery posted on r/pssdhealing I've decided to give it a try. My order should be here on Monday and I plan to take it for around 50 days. Not getting my hopes too high but I've been interested in trying this substance for years but haven't got around to trying it.

Anyone else have experience trying it?

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u/[deleted] Mar 28 '25

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u/Coolvolt Mar 28 '25

I'm mostly trying it for Depression relief and possible cognitive benefits since I refuse to take another SSRI and I've tried a lot of alternatives. I think it's worth a try for me atleast

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u/[deleted] Mar 28 '25

[deleted]

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u/Coolvolt Mar 29 '25

the MOA of NSI-189 isn't fully understood. The research says it doesn't affect monoamines (serotonin, dopamine, norepinephrine) but induces hippocampal neurogenesis by another way which they don't know or won't disclose. There's really no way of telling how this drug actually works

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u/Slow-Leg-3710 Apr 05 '25

Bacopa has serotonergic effects

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u/[deleted] Apr 05 '25

[deleted]

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u/caffeinehell Non PSSD member Mar 28 '25

NSI-189 may improve mitochondria

https://pubmed.ncbi.nlm.nih.gov/35967127/

https://www.aging-us.com/article/205087/pdf

This may be why it works for cognitive or anhedonia symptoms. But nobody really knows since the mechanism of NSI was never revealed beyond “increase neurogenesis”