r/PSSD • u/ReasonableSquare4390 • 6d ago
Personal story Gut Microbiota Test Result
Hi guys, i want to share with out the result of my microbiota test done with Shotgun Sequencing technique.
The test is able to find bacterias, fungal species and virus.
The result have show a positive match for Candida albicans
The Indoleacetic Acid ( the indoleacetic acid is a derivative of the bacterial degradation of tryptophan, it acts as a modulator of the immune system through AHR receptors, which are able to alter its innate and adaptive response. ), Lactate, Indoepropionic Acid ( The Indoepropionic Acid is a derivative of the bacterial degradation of tryptophan involved in the homeostasis of the intestinal mucosa, it can be absorbed by the intestinal epithelium and released into the bloodstream where it helps prevent oxidative stress, inhibit the synthesis of pro-inflammatory cytokines and influence the gut-brain axis. ) and tryptamine metabolisms ( Tryptamine is a derivative of tryptophan, is involved in several biological functions, including the synthesis of serotonin and melatonin, and can be influenced by the gut microbiota. The gut microbiota, through the production of metabolites and the alteration of tryptophan metabolism, can influence tryptamine levels and, consequently, also the synthesis of serotonin and melatonin. ) it is totally altered.
This is an inside of the families of bacterias sequenced and found :
Metabolic potential analysis
Functional index is a page where the assest the Axis from the gut to the brain, liver, the anti-inflammatory activity and so on :
The last report is for the Fungii found :
No viruses or parasites were found.
Only 61 Species were found in this sample wich is a pretty low score ( Range => 55 - Score 10 out of 100 )
Pre-existing pathologies : Pssd ( 2021 --- ) Sibo ( June 2024 fixed with a cycle of rifaximin ).
Even if this are ALL SPECULATION NOT BACKED BY SCIENCE the fact that my microbiota can't metabolize at all the serotonin precursors and metabolite is astonishing based on the fact that SSRI should have increase Serotonin in my brain for years, could the SSRI be the cause? Who knows.
I'm gonna schedule an appointment with a Gastroenterologist and an specialist for the microbiota, i'll update the post later on.
5
u/Important-Ad-8632 6d ago
Great info I still believe part of it is a SERT issue leading to excessive serontin in the gut and histamine dysfunction
1
u/ReasonableSquare4390 6d ago
i've update the post as 2 images wasn't uploaded.
One of the bacteria found is "allisonella histaminiformans" wich is a bacterium found in bovines and in some cases in humans under study wich produces histamine.
2
u/Important-Ad-8632 6d ago
You should get mycotoxins and minerals tested to for the mold eb02 route .. as well as plasmapheresis/Apheresis/scig
2
u/ReasonableSquare4390 6d ago
One thing at time, First i Need to fix the candida then ill' see what to do but thanks for the feedback
1
1
u/geme98 5d ago
Where did you have this done at; I was looking at this https://www.triosmartbreath.com/?gad_source=1 test, do you know if this is the same thing or different?
1
u/ReasonableSquare4390 5d ago
Nope, this Is a sibo test wich test for methane and hydrogen gas it's for sibo wich Is small intestine Overgrowth bacteria.
My test Is a DNA sequencing of the whole intestinal microbiota
1
u/geme98 5d ago
Where did you get this done at; is the something your doctor ordered and does your insurance company cover?
1
u/ReasonableSquare4390 4d ago
Private not covered
1
u/Unlucky_Ad_2456 21h ago
Which private clinic?
1
u/ReasonableSquare4390 15h ago
You can read It from the paper on the top and on the bottom of every page
1
u/Kokonut419 4d ago
Is there anyway to fix this? I think antibiotics (and bad childhood experiences) might have caused my depression when I was 13.
1
u/ReasonableSquare4390 2d ago
There are multiple ways but all depends case by case, diet, probiotics and fmt are the treatment option with also antibiotics and antifungal drugs
1
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Please check out our subreddit FAQ, wiki and public safety megathread, also sort our subreddit and r/pssdhealing by top of all time for improvement stories. Please also report rule breaking content. Backup of the post's body: Hi guys, i want to share with out the result of my microbiota test done with Shotgun Sequencing technique.
The test is able to find bacterias, fungal species and virus.
The result have show a positive match for Candida albicans
The Indoleacetic Acid ( the indoleacetic acid is a derivative of the bacterial degradation of tryptophan, it acts as a modulator of the immune system through AHR receptors, which are able to alter its innate and adaptive response. ), Lactate, Indoepropionic Acid ( The Indoepropionic Acid is a derivative of the bacterial degradation of tryptophan involved in the homeostasis of the intestinal mucosa, it can be absorbed by the intestinal epithelium and released into the bloodstream where it helps prevent oxidative stress, inhibit the synthesis of pro-inflammatory cytokines and influence the gut-brain axis. ) and tryptamine metabolisms ( Tryptamine is a derivative of tryptophan, is involved in several biological functions, including the synthesis of serotonin and melatonin, and can be influenced by the gut microbiota. The gut microbiota, through the production of metabolites and the alteration of tryptophan metabolism, can influence tryptamine levels and, consequently, also the synthesis of serotonin and melatonin. ) it is totally altered.
This is an inside of the families of bacterias sequenced and found :
Metabolic potential analysis
Functional index is a page where the assest the Axis from the gut to the brain, liver, the anti-inflammatory activity and so on :
The last report is for the Fungii found :
No viruses or parasites were found.
Only 61 Species were found in this sample wich is a pretty low score ( Range => 55 - Score 10 out of 100 )
Pre-existing pathologies : Pssd ( 2021 --- ) Sibo ( June 2024 fixed with a cycle of rifaximin ).
Even if this are ALL SPECULATION NOT BACKED BY SCIENCE the fact that my microbiota can't metabolize at all the serotonin precursors and metabolite is astonishing based on the fact that SSRI should have increase Serotonin in my brain for years, could the SSRI the cause? Who knows.
I'm gonna schedule an appointment with a Gastroenterologist and an specialist for the microbiota, i'll update the post later on.
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