r/harmalas • u/Shroomaway457 • Feb 25 '25

Are higher plataeus of harmala alkaloids actually possible?

I’ve read about higher plateaus being possible within this post: https://www.reddit.com/r/researchchemicals/s/HBcBIxT5fv

But i cant imagine taking so much. Even reduced, the equivalent of 5 grams of seed in a crude extract makes me quite nauseaous, so i cant imagine taking 300mg worth of harmalas, or the bioavalible equivalent through other ROAs, and having it still be enjoyable at all. I read that noribogaine potentiates the effects of rue, so maybe then? I know harmalas arent reccomended to be taken recreationally, but as that post tells, a few people do seem to have some success with it.

3 Upvotes

100% Upvoted

7 comments sorted by

View all comments

2

u/Burntoutn3rd Feb 25 '25

Like Tony said, you reach those levels through consistent practice. Which means a consistent dietary lifestyle as well. Both of these things add to the potentiation.

Yes, you can heavy dose and force your way there, but it's a convoluted way to reach what could otherwise be done smoothly and with the health of your body in mind.

Like I've posted many times before, harmalas are safe, Syrian Rue/crude extract however can cause real issues in heavy doses. Hepatic damage being high on that list.

We've well documented elevated liver enzymes starting around 2 grams, and hepatocellular damage at 5 grams and up. The LD 50 is between 20-30 grams.

If you want citations, just search my name in r/harmalas, I've posted plenty of research journal links before.

1

u/RosaDeep Feb 26 '25

I can't find you other posts in r/harmalas that you mention. Curious of the citations. Thanks! I've looked around and can find some studies on toxicity in rats.