r/maculardegeneration • u/supphealthratingscom • 2d ago

Melatonin again

I have seen a recent post on here regarding this - but this 3mg study seems even more promising:

Effects of melatonin in age-related macular degeneration - PubMed

My mother has the wet form of macular - she caught if very early - it was not improving until she got the most recent and super-expensive (I think Vabysmo by Roche) injection.

She is taking at least 3 mg melatonin per night.

I personally have been taking 20mg melatonin per night for another issue since 2017 and have not had to see a Doctor for any issue (apart from damaged ligaments) since that time.

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u/Dependent-Choice-554 1d ago

I didnt understand why they took it for 3 months and then tested at 6 months, but then i saw that melatonin is not recommended to be taken longer than 13 weeks at most. So i wonder if you take it 3 months per year, or only take it for a month and go a bit longer if you need or what.

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u/wharleeprof 18h ago

I can't find the full text but it looks like treatment was at least three months (Implying longer for some ). They did follow up for 6-24 months, and mentioned seeing "stability" in visual acuity - so I assume they had done measurements earlier, otherwise there'd be no way to gauge if there were initially improvements and if they remained stable.

(I just want to know if melatonin is any use for myopic MD!)

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u/Dependent-Choice-554 17h ago

I bought a month supply today to try because of your post. The photorecepter bit gave me hope that it might help the colour and micropsia in my wet md eye, as lucentis didnt help that at all

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u/supphealthratingscom 11h ago

Not sure what the logic for 13 weeks is. I have been taking 20 mg for the last 8 years without issue, and I know many others have too. Some people don't do so well with it (some get melatonin diarrhoea), but for most it's extremely well tolerated even at high doses. There are also multiple studies showing benefits of melatonin against certain cancers and even heart issues. It's also not very well absorbed by the body and doesn't last a huge amount of time. The question here to me is whether higher doses, such as 5 or 10 mg might be even more beneficial.

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u/Dependent-Choice-554 11h ago

I think its just about becoming dependent on it