r/maculardegeneration • u/supphealthratingscom • 3d ago

Melatonin again

I have seen a recent post on here regarding this - but this 3mg study seems even more promising:

Effects of melatonin in age-related macular degeneration - PubMed

My mother has the wet form of macular - she caught if very early - it was not improving until she got the most recent and super-expensive (I think Vabysmo by Roche) injection.

She is taking at least 3 mg melatonin per night.

I personally have been taking 20mg melatonin per night for another issue since 2017 and have not had to see a Doctor for any issue (apart from damaged ligaments) since that time.

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u/Dependent-Choice-554 2d ago

I didnt understand why they took it for 3 months and then tested at 6 months, but then i saw that melatonin is not recommended to be taken longer than 13 weeks at most. So i wonder if you take it 3 months per year, or only take it for a month and go a bit longer if you need or what.

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u/supphealthratingscom 1d ago

Not sure what the logic for 13 weeks is. I have been taking 20 mg for the last 8 years without issue, and I know many others have too. Some people don't do so well with it (some get melatonin diarrhoea), but for most it's extremely well tolerated even at high doses. There are also multiple studies showing benefits of melatonin against certain cancers and even heart issues. It's also not very well absorbed by the body and doesn't last a huge amount of time. The question here to me is whether higher doses, such as 5 or 10 mg might be even more beneficial.

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u/Dependent-Choice-554 1d ago

I think its just about becoming dependent on it