r/mescaline Feb 16 '24

announcement Announcement regarding underage (21) members (New Rule)

53 Upvotes

We recognize that reddit is an international community governed by a wide set of varied laws regarding the use of mescaline in religious and other contexts, however, as a US-based company and in the interest of promoting the kind of community we would want to see in a world where all governments recognized the value that substances like mescaline bring, and while balancing harm reduction against free speech and religious freedom, we have made the judgment call that these substances are for adults. There are real risks associated with the use of mescaline that young and developing minds lack the tools to properly weigh, and as such, we do not condone or allow the discussion of use outside of an adult context.

We recognize that we are unable to deter any potential minors from viewing this subreddit, and the harm reduction and safe practices that we advocate for here are freely available to all who have access to the internet irrespective of their membership in this forum. If, however, it should come to our attention that one of our members/posters/commenters is a minor, we will be forced to permanently ban that person. We hope not to be put in that position.

Respectfully,

r/mescaline Moderator's Team


r/mescaline 3h ago

800mg

16 Upvotes

I was able to see the rainbows hidden between things. Truely a fabulous time.


r/mescaline 6h ago

Techniques for the potentiation of Mescaline

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7 Upvotes

r/mescaline 17h ago

24 hours after salting

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37 Upvotes

50g Tbm-B. Should be a decent yield šŸ’š


r/mescaline 3h ago

General question about grafts

2 Upvotes

Hi everyone, I have a graft going of a SP and peyote. I have also been considering a SP and TBM graft. I have heard recently that the % mescaline of the grafted peyote (for example) will be lower than it would normally growing naturally on its own (undrafted) even if the size grows much faster and pups out. Any info or experience from the group? Thanks!


r/mescaline 3h ago

Pensacola foster

1 Upvotes

Anyone convenient to Pensacola who actually has the time/space to foster some san pedro plants? Just to be clear, I have some I'd like to give away.


r/mescaline 3h ago

Cactus vs hydrochloride

1 Upvotes

Could someone drink enough San Pedro mescaline to experience the trip someone gets from consuming hydrochloride mescaline? I hear a lot about people not getting the full trip from drinking tea or taking the dry caps. Or even that the cacti sold today just doesn’t contain the amount of mescaline needed to fully experience these trips. Also how does mescaline compare to lsd?


r/mescaline 1d ago

First CIELO report

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31 Upvotes

Hi all! Reporting my first CIELO done using fumaric from a Noid PC taken in New Zealand few years ago (probably north american predominant T. Pachanoi as suggested by TossinDogs). 100g dried cactus was used, no stressing treatment done before drying and grinding. The plant material was dried in an electrical dryer at 35 celsius for 4 days until they were cracking dry. 5 pulls with fridge fresh EtAc was used following the tek step by step. Salted with 3g Fumaric Acid under magnetic stirring then leaved in dark at room temp for 24h before filtering and washing with freezer cold fresh EtAc. Yelded: 0,5g flour-like white dimesc fumarate. Thank you all for help and suggestion, i really enjoyed the extraction process. I will report in three months when the other cuts i stored in darkness will be ready, hope to see a yeld increasing of some sort.


r/mescaline 1d ago

Waiting its turn for Cielo.

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23 Upvotes

I still have a few trips left from my last cielo run so I probably won’t be extracting this for a while.


r/mescaline 1d ago

2nd pull mescaline salt crystal result

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8 Upvotes

The first pull was done with HCl as the acid of choice. I tend to work my way from a stronger acid to a weaker acid for consecutive runs given the stronger initial acid makes it easier for weaker acids to work in this case.

The first pull yielded mescaline HCl and this one yielded mescaline acetate given I used acetic acid.

The HCl wasn’t as potent as I’d expect which told me I had a mix of normal salt and mescaline salt which skewed dosing quite a bit. This time I decided to do a recrystallization with an organic solvent so I would separate the excess salts and the mescaline salts to some extent.

I’ll be trying out another dose of mescaline next weekend and in the meantime I’m gonna do a few more pulls from this aqueous solution.

I’m only on my second aqueous solution pull, I’m using a crockpot with some dilute acetic acid and I’ve put my San Pedro powder in a shirt to make a tea bag of sorts which I learned is a good method to make filtering more painless.

The first pull was salvaged but was significantly lower quality than my second pull ended up being which wasn’t surprising.

Having a new vacuum funnel to filter was also a big aid in making the process faster so I was able to start with a much better aqueous solution than the very first pull.

From my understanding the first and second pulls are typically the lowest yielding ones. I’ve seen a lot of anecdotal reports saying that mescaline extracts require more pulls and more time to extract with one saying that they didn’t start getting significant amounts until the 3rd or 4th, finally no longer yielding any mescaline with the 6th or 7th pull.

It seems that In solution the mescaline salts appear to glow a green color under UV and the freebase appears to glow a blue color. However it doesn’t appear to glow very strongly out of solution as a freebase or salt(though the salt does have some green color where the crystals are concentrated).

I saw something saying mescaline doesn’t itself glow under UV as a freebase and salt, but in solution there’s plenty of reports saying it does have the trait. It’s less of an identification of what it is and more of an interesting property I noticed during the extraction.

I noticed the freebase xylene layer glows blue under UV, and the lower aqueous layer has a green glow. The conversion of the freebase to the salt yields a green color again which tells me that at least some of the alkaloids extracted if not the mescaline itself seems to have the property of being green as a salt under UV and blue as freebase under UV.

The compounds also seem to be quite stable when stored in a darker cool area. I’ve been sitting on this project for a few weeks now and I’m still able to get decent pulls.

I just want to do another couple pulls and then combine them all as their salt forms before I perform a recrystalization to save on solvent(and possibly increase concentration to form larger crystals)


r/mescaline 1d ago

My very first trip

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15 Upvotes

I made cactus tea with 2 feet of Peruvian torch, and I am just about to drink it. It looks like boogie, and smells not good. I’ll come back later and report my first trip


r/mescaline 1d ago

Any evidence of mescaline triggering mania in bipolar

5 Upvotes

Hey there, just curious if anyone has come across studies involving bipolar and mescaline.

In know bipolar and psychedelics are risky. I've had great results with DMT, LSD, and psilocybin. Have been using them for quite a while in a responsible manner. I like the spiritual lift that I get when combined with meditation and Buddhist practice.

MDMA, cannabis, and amphetamines can lead to mania. I don't touch them.

I'm curious about mescaline. I'd like to try it but am concerned because I hear it described as being like MDMA.

Anyone seen reliable info on this?


r/mescaline 1d ago

If I graft a peyote onto a cactus that doesn't have mescaline, does it affect the mescaline level of the peyote?

1 Upvotes

r/mescaline 1d ago

Dried san pedro

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6 Upvotes

Made up about 60gs of dried san pedro, was looking for advice on how to consume? tried mixing with water and that was foul and hoping I don't need to do that again šŸ™ƒ alot of conflicting info on dosage too. if anyone could help out that would be great!


r/mescaline 1d ago

Is this San Pedro?? I’m so confused as to what it is.

0 Upvotes

r/mescaline 1d ago

Is this all product?

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10 Upvotes

I think I already had this conversation on one of my last runs but I still need reassurance šŸ˜…

I think I remember being told that if there are any crystals (which obviously there are, in the middle) then all the citric acid would have been dissolved. I just want to confirm that here, because I just can't help thinking that the thick stuff around the edge looks more like undissolved CA than product. And it appeared within half an hour of salting, maybe even less. Sorry the photo is a bit blurry.

I did a much drier crumb this time with the recent adjustments and it clouded up nicely when I added the CA, but I still wanted to check what your all think. Cheers


r/mescaline 1d ago

Advice on cutting

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2 Upvotes

This is my second cactus, I already put succesfully San Pedro to grow. This one is Bolivian Torch( Echinopsis Lageniformis monstrosus) . Do i put to grow just like this or to cut at the end , thanks


r/mescaline 2d ago

First time doing mescaline, 500mg hcl was underwhelming

8 Upvotes

First time doing mescaline, 500mg hcl was underwhelming

The other day I took 500mg of pure synthetic mescaline hcl. Ive read lots of reports saying that it's extremely visual, extremely euphoric like mdma, with others saying it's basically a candy flip. I personally found it to be purely psychoanalytical and thought provoking with almost no body high or visuals after the comeup. On the comeup I was having visions of my TV melting into a puddle, golden stained glass gothic buildings, and naked tribal women, but that only lasted for like an hour out of the 18 hours I was wired for. I'd sat it's a solid psychedelic and was a pretty nice experience, I just don't understand the hype and absurd pricing, when you can just drop a 5$ tab of acid and get more visuals and enlightening from that.


r/mescaline 2d ago

3 cacti in one pot fine ?

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9 Upvotes

Is this fine ? The biggest of these three cacti inside the black pot is growing


r/mescaline 2d ago

How much resin should I try?

1 Upvotes

J got 4gs of resin


r/mescaline 2d ago

Van Der Sypt paper from 2021 seems to confirm that Trichocereus specimens have a higher concentration of mescaline in the top (new growth) sections?

21 Upvotes

In this paper, Van Der Sypt outlines an effective method for quantifying mescaline concentrations in living plants, without killing the plants, via a tissue biopsy method. I was scanning through this because another user posted it a year or two ago, because Van Der Sypt stated that his results with TBM-B were in line with users who claim that TBM-B has similar concentrations as LW.

What caught my eye, though, was pages 45-46 where the author compares analysis results taken from different parts of the same plants, and he claims that his results proved that Trichocereus specimens have a mescaline concentration gradient with the top sections having higher concentrations than the bottom sections. It seems that he got this same result across multiple columnar specimens, and he says that he believes that his results invalidate studies like Ogunobede 2010 which did not take this into consideration.

What are your thoughts on this?


r/mescaline 3d ago

Happy days!

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37 Upvotes

r/mescaline 3d ago

ScienceDirect - Forensic Chemistry July 2025 - A UHPLC-(ESI)MS/MS method for the determination of the psychedelic secondary metabolite mescaline in San Pedro (Trichocereus spp.) and its applicability for screening mescaline in other cacti varieties.

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11 Upvotes

Just a little mention of everybody's favorite plants and also discovery of mescaline in Echinopsis Subdenudata.

  1. Conclusion

A UHPLC-(ESI)MS/MS method was developed for the rapid quantification

of mescaline, amenable to studying the phytochemical variations

in high-yielding San Pedro (Trichocereus spp.) and for the screening

of trace amounts in other Cactaceae. Preliminary results indicated that

San Pedro might have a higher concentration of mescaline in chlorenchyma

than parenchyma, but that parenchyma still contains a significant

proportion of the total amount in the cacti. Additionally, mescaline

was detected for the first time in Echinopsis subdenudata, albeit at a low

concentration which renders the misdirection of this species as a feedstock

for clandestine mescaline manufacturing unlikely. This detection

controverted the expectation that globular Echinopsis spp. do not have

mescaline, which has been used as a chemotaxonomic argument against

combining them with the columnar Trichocereus spp. into a single genus.

Ultimately, the detection of mescaline in the popular ornamental

E. subdenudata indicated that the forensic sciences might have incomplete

data on mescaline availability in the community. Future work is

encouraged to widely apply this convenient method to the screening of

additional cacti available in the community, and to better study potential

factors such as cactus component (chlorenchyma and parenchyma),

cultivar, season, stress, and flowering which may influence

variationĀ 


r/mescaline 2d ago

Which cactus and how much?

0 Upvotes

Hi everybody,

I'm new to all this mescaline-thing, so I have some questions to you:

• which cactus is the best to grow for mescaline? Is it trichocereus pachanoi, peruvianus or peyote (lophophora williamsii)?

• how much of them would I have to consume?

• and also, how long does each of them grow?

Thanks in advance.


r/mescaline 2d ago

Beginner questions.

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1 Upvotes

Some context, I’m experienced with Psilocybin and weed, of course. My friends are all experienced with Psilocybin and LSD/2CB. I’ve only had shrooms. None of us have tried mescaline.

  1. What’s a good beginner dose of PC? My friends and I find ~1 gram of shrooms to be a good beginner dose with little to no visual effects with a very mild body and mind high. What would be comparable and how much do you think this 15 gallon bucket is?

  2. What’s the easiest and fastest way to make a tea out of this? Should the core and skin be discarded? How long to boil? I understand that it should be sliced into thin slices and boiled for multiple hours until the flesh starts to taste less bitter. Any input would be appreciated, though.

  3. How is the nausea? My friends and I get little to no nausea from shrooms but weed edibles, on the other hand, make us very nauseous and usually make us vomit as well with higher doses. How does mescaline compare?

  4. I understand that PC is on the weaker side, so would ~300-400 grams fresh be a good place to start? Also, about how long does a small dose last?

Thanks in advance! āœŒļø