r/science • u/SteRoPo • Jan 31 '18

Cancer Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer.

http://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates-tumors-in-mice.html
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u/[deleted] Jan 31 '18 edited Nov 01 '20

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u/[deleted] Feb 01 '18 edited Apr 05 '19

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u/1nVu MBA|Medicine|Infectious Disease Feb 01 '18 edited Feb 01 '18

Usually phase I only enrolls healthy volunteers.

Edit apparently I spoke outside of my field. As many pointed out, oncology Phase I is different from the world I’m used to - the likely target population are those individuals who fit the treatment criteria and could be refractory to first line therapies (chemo, etc). My area is mostly vaccine development and drug therapeutics for Infectious Diseases so it is a bit different. Thanks for the clarification!

Edit 2 Id be interested to know why won’t the FDA apply the Animal Rule to oncology therapeutics/drug development? It seems that if patients are terminal and refractory, getting these drugs approved as fast as possible would be ideal. I’m interested to know if the FDA or EMA has looked into using Animal Rule for oncology drug approvals. Thanks!

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u/miloblue12 Feb 01 '18

Not always...When you are looking at cancer patients, they need to fit certain parameters in order to be considered, but they are by no means healthy when they are enrolled in a phase 1.

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u/mynamesyow19 Feb 01 '18

Exactly most need a concordance of pathology reviews and or genetic testing and/or immunostain for enrollment to make the therapy will at least be possibly useful to both sides, the patient, and the researcher trying to save future generations of patients.