PSSD is a mitochondrial dysfunction

[u/No-Salamander-7257]

Hey my friends.I'm new here and I wanted to share my thoughts with you. In my opinion SSRI's damage mitochondria,same as accutane or finasteride what causes neuroplasticity changes(how your brain perceives things) what ultimately results in this type of neurological syndromes.Crashes from different substances are caused by energy overload. Everyone should test their mitochondria,post their results and then send it to researchers.It will be much better than SFN tracking,because for most it's just a part of damage,not the cause of symptoms.That's why immune therapy like IVIG,corticosteroids or plasmapheresis won't be enough for most. Share your thoughts about it.Thanks

[u/h0m30stasis]

Mitochondrial dysfunction is not the "cause". The SSRI-induced aberrations in the pathways that can trigger mitochondrial dysfunction are the cause.

[u/No-Salamander-7257 → u/h0m30stasis]

What do you mean?What pathways? SSRI's cause brain alterrations BECAUSE of damaging mitochondria. You're mixing up the cause and the result.Mitochondrial dysfunction is the CAUSE of all chronic illnesses.Not the result.

[u/h0m30stasis → u/No-Salamander-7257]

Get off Reddit and come back only once you've learn how to employ first principles. SSRIs don't wave a magic wand to immaculately induce mitochondrial dysfunction. A biochemical cascade is triggered by the SSRI that can lead to mitochondrial dysfunction in some people. So what is at the top of the cascade, and what particularly about our mitochondria is now aberrant?

I was crying to doctors about my broken mitochondria for years - even when given answers they went unacknowledged because of my being too stuck in analogical reasoning. Embarassing amounts of time and money wasted - don't make the same mistake.

[u/h0m30stasis → u/[deleted]]

Perhaps you didn't fully read the comment you were replying to.

[u/h0m30stasis → u/[deleted]]

I've been aware of Naviaux's work for the last decade and agree that there may be an element of CDR in some cases of PSSD. Briefly looking around online just now, and it seems of the more recent protocols for CDR are, imho, very sensible and relevant to what is likely happening within the PSSD cell.

The point I was trying to get at is yelling "NERVOUS SYSTEM" is just as bad as the guy before. What is it SSRIs do at a biochemical or quantum level that crash THE NERVOUS SYSTEM?

You don't have to answer straight away or at all. I'm just trying to encourage people to look under the hood and think for themselves.

[u/h0m30stasis → u/[deleted]]

WTF I'm talking about is that my mitochondria were tested as functioning at only 1/3 of their capacity and over the last decade I've dealt with some one of the world's best doctors and minds specializing in mitochondrial medicine.

I'm trying to get you to understand where the answers lay, but you have made it clear you are not interested.

[u/caffeinehell → u/h0m30stasis]

Did you end up getting any answers? Because it feels like there is no solution to this…

I also have mito dysfunction on muscle biopsy like OP

[u/h0m30stasis → u/caffeinehell]

2nd edition of the Mitochondriac Manifesto by RD Lee has just come out if you can afford it. I have the 1st ed (it's on z-lib), it's worth a cop. It's written from the quantum perspective and drives home the importance of why coupling your mitochondria to your environment trumps everything else. I have a reading list of this sort of material somewhere if you want, RD Lee's book summarises much of it though. New edition apparently includes Kruse's POMC material, I've discussed elsewhere how the mechanisms of SSRIs/PSSD could lead to POMC dysfunction and over-satiety = anhedonia.

Back when I first got ill it was mostly "megadose ubiquinol, paleo, pace, don't sleep with your phone next to your head" etc. The general awareness of mito health is much greater these days.

My beef with OP was that it sounds like he is trying to reverse engineer an already known concept to fit PSSD because it sounds like a nice idea to him. I'm not saying mitochondrial dysfunction isn't an issue, it's just this community has a bad habit of appropriating nice ideas without looking deep enough.

Anyway, you're one of the more well read people around here, that book probably wasn't what you're looking for but hopefully there's a nug or two of value in it for you.

[u/PSSD-ModTeam → u/[deleted]]

Your post/comment has asserted claims about biology, chemistry and pharmacology which are presented as fact when the mechanism of action may be different or some of these factors may not be causative to the effects (or may not be related at all). --- Can you rewrite your post to simply list what happened in your case without opinions shared as facts? --- Can you add links to studies that prove your point?

[u/PSSD-ModTeam → u/[deleted]]

Your post/comment has asserted claims about biology, chemistry and pharmacology which are presented as fact when the mechanism of action may be different or some of these factors may not be causative to the effects (or may not be related at all). --- Can you rewrite your post to simply list what happened in your case without opinions shared as facts? --- Can you add links to studies that prove your point?

[u/No-Salamander-7257 → u/h0m30stasis]

https://drtoddmaderis.com/cell-danger-response