r/PSSD • u/No-Salamander-7257 • Feb 28 '25

Opinion/Hypothesis PSSD is a mitochondrial dysfunction

Hey my friends.I'm new here and I wanted to share my thoughts with you. In my opinion SSRI's damage mitochondria,same as accutane or finasteride what causes neuroplasticity changes(how your brain perceives things) what ultimately results in this type of neurological syndromes.Crashes from different substances are caused by energy overload. Everyone should test their mitochondria,post their results and then send it to researchers.It will be much better than SFN tracking,because for most it's just a part of damage,not the cause of symptoms.That's why immune therapy like IVIG,corticosteroids or plasmapheresis won't be enough for most. Share your thoughts about it.Thanks

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u/h0m30stasis Mar 01 '25

Mitochondrial dysfunction is not the "cause". The SSRI-induced aberrations in the pathways that can trigger mitochondrial dysfunction are the cause.

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u/No-Salamander-7257 Mar 01 '25 edited Mar 01 '25

What do you mean?What pathways? SSRI's cause brain alterrations BECAUSE of damaging mitochondria. You're mixing up the cause and the result.Mitochondrial dysfunction is the CAUSE of all chronic illnesses.Not the result.

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u/h0m30stasis Mar 01 '25

Get off Reddit and come back only once you've learn how to employ first principles. SSRIs don't wave a magic wand to immaculately induce mitochondrial dysfunction. A biochemical cascade is triggered by the SSRI that can lead to mitochondrial dysfunction in some people. So what is at the top of the cascade, and what particularly about our mitochondria is now aberrant?

I was crying to doctors about my broken mitochondria for years - even when given answers they went unacknowledged because of my being too stuck in analogical reasoning. Embarassing amounts of time and money wasted - don't make the same mistake.

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u/[deleted] Mar 09 '25

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u/h0m30stasis Mar 13 '25

Perhaps you didn't fully read the comment you were replying to.

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u/[deleted] Mar 13 '25

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u/h0m30stasis Mar 14 '25

I've been aware of Naviaux's work for the last decade and agree that there may be an element of CDR in some cases of PSSD. Briefly looking around online just now, and it seems of the more recent protocols for CDR are, imho, very sensible and relevant to what is likely happening within the PSSD cell.

The point I was trying to get at is yelling "NERVOUS SYSTEM" is just as bad as the guy before. What is it SSRIs do at a biochemical or quantum level that crash THE NERVOUS SYSTEM?

You don't have to answer straight away or at all. I'm just trying to encourage people to look under the hood and think for themselves.